Physician's CHOICE Probiotics 60 Billion CFU - 10 Unique Strains + Organic Prebiotic, Crafted for Overall Digestive Health, Gut Health, Occasional Constipation, Gas & Bloating - 2 Month Supply

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The minimum recommended effective daily dose is between 100 million and 1 billion cells per day. Most probiotics contain at least 1 billion CFUs. Blaxter M, Mann J, Chapman T, Thomas F, Whitton C, Floyd R, et al. Defining operational taxonomic units using DNA barcode data. Philos Trans R Soc B Biol Sci. 2005;360:1935–43. Other ingredients: Acid-resistant vegetable capsule (HPMC, pectin), magnesium stearate (vegetable source) Escherichia coli and Enterococcus family species are commensal inhabitants of the gastrointestinal tract that may become pathogens in a dysbiotic environment for several diseases, such as antibiotic-associated diarrhea, vomiting, or permanent intestinal inflammation. Moreover, they are characterized by antibiotic resistance [ 72, 73]. Probiotic supplementation seems to reduce Escherichia overgrowth during antibiotic therapy according to Kabbani et al. and Oh et al. [ 43, 61]. Nevertheless, the level of both Escherichia and Enterococcus tends to normalize after antibiotics cessation regardless of probiotics supplementation. This brings the efficacy of probiotics in preventing this type of antibiotic induced dysbiosis into question [ 52, 59, 61]. Our probiotic contains 60 billion live and active microbes in each serving at the time of manufacturing. This high-potency formula allows a greater chance of healthy microbes colonizing in your gut. We ensure maximum concentration and effectiveness with zero unnecessary binders, GMOs, gluten, colors, preservatives, or other additives. Synergistic support

Excess gas can be caused by an imbalance of lactic acid in your gut. Our probiotic formula contains Bifidobacterium and Lactobacillus strains that can produce lactic acid and help reduce odorous gas. Gives your gut the support it needs Research strongly supports the benefits of probiotics for the digestive system, including evidence that these healthy bacteria improve symptoms associated with several intestinal conditions. Since probiotics must make it through the stomach to be effective, the beneficial properties of a probiotic product depend on its survival in a harsh, acidic environment. Physician’s Choice delayed-release capsules are acid-resistant, offering a critical layer of protection to keep the probiotic organisms viable on their journey to the intestines. Changes in the level of Enterobacteriaceae family were inconsistent across the studies. Several articles reported an increasing trend of Enterobacteriaceae in the probiotic supplemented group only [ 55, 62]; however, according to other studies [ 57, 58], this increase was observed only in the control group. Meanwhile, Forssten et al. and MacPherson et al. reported a higher relative abundance of Enterobacteriaceae in both groups after antibiotic treatment, which normalized after 2 weeks of follow-up [ 51, 63]. Changes in the other bacterial families were heterogeneously reported (see Tables S 3 and S 4).

Probiotic FAQs

Antibiotic treatment affects the gut bacterial microbiota quantitatively and qualitatively, causing a decrease or even extinction of certain species, leading to a low-diversity microbiome, and allowing some potentially harmful bacteria to become dominant, e.g., Clostridium perfringens, Staphylococcus aureus, or Clostridioides difficile [ 1, 2]. This microbial imbalance is called dysbiosis. The deviation from the normal microbiome has been linked to obesity, malnutrition, inflammatory bowel disease, neurological dysfunctions, and cancer [ 3]. The gut microbiota can spontaneously recover, but it is influenced by various host and external factors like age, health status, the geographical area of origin of patients, dose, duration, and the spectrum of antibiotic treatment [ 4, 5, 6]. Young, healthy adults have stable microbial community functions [ 7], but repeated perturbation of the ecosystem is particularly detrimental if there is insufficient time for recovery after the initial impairment. Previous research has shown that the gut microbiota recovers within about 2 weeks after a single antibiotic exposure in adults, but repeated exposures can significantly prolong the recovery time [ 4, 8, 9, 10]. Madden JAJ, Plummer SF, Tang J, Garaiova I, Plummer NT, Herbison M, et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2005;5:1091–7. Gotelli NJ, Colwell RK. Estimating species richness. In: Diversity Biological, editor. Frontiers in Measurement and Assessment. Oxford University Press: United Kingdom; 2011. p. 39–54.

PRO biotika jsou živé mikroorganismy s výhodnými účinky vůči zdraví. Často se označují za "přítelské" nebo "dobré" bakterie, které podporují imunitní systém, střeva a celkové zdraví. Existují přirozeně v trávícím traktu a pomáhají chránit proti škodlivým bakteriím a plísním.Hanchi H, Mottawea W, Sebei K, Hammami R. The genus Enterococcus: between probiotic potential and safety concerns-an update. Front Microbiol. 2018;9:1–16. At genus level, Bacteroides showed a decreasing trend in the probiotic supplemented group [ 53, 55, 57]. However, some studies reported a reduction of Bacteroides in both groups after antibiotic treatment, which showed a re-growing tendency during 3–8 weeks of follow-up [ 52, 58]. Patients with probiotic supplementation had a higher proportion of Escherichia spp. according to Cárdenas et al. [ 55], while two other studies reported that the addition of probiotics reduced the overgrowth of Escherichia compared to the control group [ 43, 61]. According to the study of Tang et al., where probiotic supplementation was continued for two more weeks after antibiotics cessation, the abundance of genus Enterococcus increased at weeks 2 and 4 of follow-up in the intervention group only [ 52]. Meanwhile, Wang et al. reported this increasing tendency in both groups at week 2. In their study, probiotics were suspended after the antibiotic cessation. However, by weeks 6, 8, and 9 of follow-up, the enrichment of Enterococcus had disappeared in both intervention and control groups as reported in both of the studies [ 52, 59]. Probiotic supplementation seems to help maintain the level of Bifidobacterium genus [ 50, 54, 62]. According to Plummer et al., Bifidobacterium decreased in both groups during antibiotic therapy but tended to increase after therapy cessation to day 35 of follow-up [ 58]. In the study of Kabbani et al., Roseburia prevalence was decreased by antibiotic treatment only; however, Tang et al. reported a significant reduction in both groups [ 52, 61]. Probiotic supplementation resulted either in an increase of Blautia in the intervention group or decrease in the control group only according to two studies [ 50, 54]. However, Tang et al. described a lower abundance of Blautia in both groups after antibiotic treatment, with a re-growing tendency with time regardless of probiotic supplementation [ 52].

Hegyi P, Petersen OH, Holgate S, Erőss B, Garami A, Szakács Z, et al. Academia europaea position paper on translational medicine: the cycle model for translating scientific results into community benefits. J Clin Med. 2020;9(5):1532. Pollutants, antibiotics, alcohol, smoking, stress, junk food, and aging can all negatively affect your gut’s friendly bacteria. Our complete probiotic and prebiotic formula helps restore the balance of your microbiome naturally. Supports healthy digestion Roswell M, Dushoff J, Winfree R. A conceptual guide to measuring species diversity. Oikos. 2021;130:321–38. It is important to note that more research is needed to determine the most effective dose, length of treatment, and strains of probiotics for IBS.Oh B, Kim BS, Kim JW, Kim JS, Koh SJ, Kim BG, et al. The effect of probiotics on gut microbiota during the Helicobacter pylori eradication: Randomized Controlled Trial. Helicobacter. 2016;21:165–74. Mezzasalma, V., et al. (2016). A randomized, double-blind, placebo-controlled trial: The efficacy of multispecies probiotic supplementation in alleviating symptoms of irritable bowel syndrome associated with constipation. Strong WL. Assessing species abundance unevenness within and between plant communities. Community Ecol. 2002;3:237–46.