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The exisiting research on saffron suffers from several flaws: saffron standardization hasn’t been established, most of the studies were conduced only in Iran, and an effective dosage still hasn’t been specified. Side Effects of Saffron Limited studies show that saffron might help with PMS, irregular periods, and cramps, but more research is needed. Insufficient Evidence: In a recent trial of 60 patients who were overweight and had high cholesterol, subjects were treated with a combination of bergamot extract and artichoke leaf extract for 2 months and compared to a group that received a placebo for the same amount of time. The results showed a significant decrease in total and LDL cholesterol as well as a significant reduction in waist circumference.
A study in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilized to prevent bias in research results. Double-blind studies are particularly useful for preventing bias due to demand characteristics or the placebo effect.The aim of this study was to assess the the effect of saffron extract on sleep quality and melatonin concentrations in participants with poor sleep quality. The active treatment contained 14 mg (low-dose) or 28 mg (high-dose) of saffron product, standardized to more than 3.5% lepticrosalides, a measure of the bioactive compounds in saffron (including safranal and crocin isomers). The placebo tablets contained microcrystalline cellulose and calcium hydrogen phosphate. All participants took one tablet daily, one hour before bedtime, with or without food, for 28 days. Forty participants were randomly assigned each to the low-dose saffron extract, high-dose saffron extract, and placebo groups. In mice with liver damage, saffron decreased levels of highly toxic proteins and fat deposits in the liver [ 40]. Saffron may improve heart function by increasing its pumping capacity. This may be due to the presence of kaempferol, a molecule with potent heart-protecting effects [ 34, 35, 36]. In epileptic mice, saffron’s active ingredient safranal was able to suppress seizures. This is due to binding at the GABA-A receptor, similar to the way benzodiazepine drugs (Xanax, Valium) prevent certain types of seizures (absence seizures) [ 1]. 22) Diabetes
The authors concluded that the effect of crocin had a positive impact of symptoms of depression and could be considered for administration in the treatment of in MDD There is also some evidence to suggest that saffron may help promote weight loss and curb the appetite. Made from some the world’s most potent organic saffron, Saffrosun for Children contains the highest strength of bioactive at a strength of 3.5% of all three active components (crocin, saffranal & picrocrocin) per capsule, which have been proven to improve psychological balance, tiredness and help you feel rested and refreshed on waking. In a study of 28 healthy men, saffron supplementation for 10 days increased muscle strength and improved reaction time. This is likely due to improved mitochondrial function (antioxidant activity) and procognitive effects [ 33]. There is also growing evidence that saffron may help improve mood and be a useful addition to treatment for depression.
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Taking to control cravings. Found it does suppress appetite and boosts mood. Not a miracle drug though.”
Similarly, in another study, saffron tablets reduced blood pressure in higher doses (400 mg) in 30 adults after one week [ 24]. SAFFROSUN CALM– has been proven to promote restful sleep, balance the stress response and enhance energy levels. With Childhood Depression and Anxiety on the rise, Saffrosun For Children is launched: ‘Nature’s Prozac’ – a saffron-based supplement clinically proven to reduce symptoms of Emotional Imbalance Saffrosun for Children is a natural remedy, made with organic Saffron extract at a clinically effective strength, with helpful prebiotic and food-sourced Vitamins D and B12.After menopause, many women suffer from issues with bone health resulting in conditions like arthritis and osteoporosis. This occurs due to changes in hormone (estrogen) levels that are responsible for maintaining bone health. In 45 healthy people, saffron extract taken for 3 months significantly increased white blood cell and antibodies count (IgG and monocytes) compared to placebo [ 32]. Researchers reviewed the effects of saffron on male infertility problems and noted that while it had a positive effect on erectile dysfunction and overall sex drive, it did not change the viability of the semen.
In another study on rats, the daily use of saffron inhibited the production of ulcers caused by excessive histamine or stress [ 53]. If you suffer from headaches and migraines you may be reaching for painkillers such as Ibuprofen which, although an effective anti-inflammatory, has long term side effects including increasing cardiovascular risks and damaging the protective lining of the gut. Ibuprofen is only effective for up to 6 hours, so you may need to take repeated doses!In rats, scientists observed the ability of saffron extract to protect against drug-induced liver damage [ 60]. Crocetin is thought to increase serotonin levels in the brain, which might explain its potential antidepressant and anxiety-relieving effects [ 1]. The below doses may not apply to you personally. If your doctor suggests using 7-keto DHEA, work with them to find the optimal dosage according to your health condition and other factors. By targeting core aspects of depression and anxiety, saffron works far more rapidly than the pharmaceuticals, which are shooting at the wrong target. In a rat model of osteoporosis, saffron extract given for 16 weeks was able to prevent disease progression. This was likely mediated by an increase in estrogen levels, which promotes healthy bone growth [ 50, 8]. 17) Asthma
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