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After a few weeks, I started to realise I was getting a much better sleep at night,’ Louise remembers. ‘My brain isn’t giving me the annoying ‘updates and analysis’ of everything that has been going on throughout the day. My boyfriend says that I am less moody and I am actually able to plan ahead without feeling under pressure. Basically, I can breathe again.’
A randomized, double-blinded, parallel-group design was used. After screening, participants were randomly allocated to the probiotic or placebo group for 4 weeks. At baseline (visit 1) and 1 day after completion of the intervention period (visit 2), measurements of resting-state MEG, MEG during CBG, and related questionnaires to measure the level of distress were performed. Structural MR images were acquired on a different day, regardless of the intervention schedule. To record participants health and quality of life status, participants completed the 36-item short-form health survey (SF36) ( 20) at the beginning of each of the 2 visits. The SF36 includes 8 subscales: physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to personal or emotional problems, emotional well-being, social functioning, energy/vitality, and general health perceptions. The randomization scheme was only unblinded after completion of the experiment and complete data evaluation. Materials Zenflore, with the unique 1714-Serentitas culture and specially selected B vitamins, provides support for your mind and body during busy and demanding times, reduces fatigue and supports mental performance.* B. longum 1714™ altered resting-state neural oscillations, with an increase in theta band power in the frontal and cingulate cortex ( P< 0.05) and a decrease in beta-3 band in the hippocampus, fusiform, and temporal cortex ( P< 0.05), both of which were associated with subjective vitality changes. All groups showed increased social stress after a 4-week intervention without an effect at behavioral level due to small sample numbers. However, only B. longum 1714™ altered neural oscillation after social stress, with increased theta and alpha band power in the frontal and cingulate cortex ( P< 0.05) and supramarginal gyrus ( P< 0.05). DISCUSSION: Firstly, your gut is responsible for the production of neurotransmitters that affect mood and regulate sleep such as dopamine, gamma-aminobutyric acid (GABA) – a key sleep modulator – and serotonin. ‘In fact, 90 per cent of the serotonin in the body is produced by the gut,’ says Dr Thomas.
It is known that the health of our gut has a direct correlation to brain function. ZenfloreⓇ has been specifically formulated to encourage serotonin production in the gut, which elevates our mood and to utilise the stress and fatigue-reducing properties of selected B vitamins. ZenfloreⓇ has undergone rigorous clinical trials and human studies and has also been shown to reduce levels of cortisol, the stress hormone.
The existence of bidirectional communication between the gut and brain has long been established. Recently, a body of work has suggested that the commensal gut microbiota plays an important role in modulating the gut-brain axis, possibly through immune, endocrine, and neural system pathways ( 1). This has led to increased interest in modulating the gut microbiota to target central nervous system (CNS) functions and improve human behavior especially in areas such as stress, mood, anxiety, and cognition. Probiotics may represent a safe and effective way of targeting CNS function. Indeed, an abundance of preclinical studies have shown that probiotics acting through the gut-brain axis can affect brain development, function, and behavior ( 2). However, the translation of promising preclinical signals into human subjects with certain probiotic strains has proven challenging ( 3). Therefore, there is a need for more detailed mechanistic insights into the interaction between the gut microbiota and brain function in humans.This exciting product is a type of supplement that through scientific research has shown that it can influence brain function. The bacteria in our gut can beneficially influence the brain response to everyday stress, can communicate directly with the brain via the central nervous system and are now considered vital to brain health. This link is known as the gut-brain axis. The gut-brain axis Generally, it takes around two months for the average gut to recover from one course of antibiotics and you can improve this recovery time with a gut-friendly diet of probiotics (the healthy bacteria) and prebiotics (which feed the healthy bacteria and help it grow). In this study, we explored the effect of B. longum 1714™ on brain function in response to social stress in a randomized, double-blinded, placebo-controlled trial, using the neuroimaging method magnetoencephalography (MEG). Social stress was induced by social exclusion/rejection ( 11) through a standardized paradigm, called “Cyberball Game” (CBG) ( 12). According to a recent review summarizing previous neuroimaging studies on the CBG, regions of the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and temporal cortex are involved in neural processing of this type of social stressor ( 13). Indeed, social stress during the CBG is consistently associated with altered neural oscillations in certain brain areas, such as alpha band power in frontal cortex and theta band power in the ACC and insula ( 14–17).
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