Lemsip Max Cold and Flu Blackcurrant Sachets, With Paracetamol, Pack Of 10 (Packaging May Vary)

Product Information

Liver damage is possible in adults who have taken 10 g or more of paracetamol. Ingestion of 5 g of more of paracetamol may lead to liver damage if the patient has risk factors (see below). Healthcare (UK) Ltd, Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications,

Monoamine oxidase inhibitors (including moclobemide): hypertensive interactions occur between sympathomimetic amines such as phenylephrine and monoamine oxidase inhibitors (see section 4.3). Additional symptoms may include, hypertension, and possibly reflex bradycardia. In severe cases confusion, seizures and arrhythmias may occur. However the amount required to produce serious phenylephrine toxicity would be greater than that required to cause paracetamol-related liver toxicity.

This medicinal product contains 128.71 mg sodium per dose, equivalent to 6.4 % of the WHO recommended maximum daily intake for sodium. influenza, including the relief of aches and pains, sore throat, headache, nasal congestion, lowering of temperature and chesty coughs Symptoms of paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect. The product should not be used during pregnancy unless recommended by a healthcare professional (see section 4.6).

The median time to maximum plasma concentration (t max) was 35 minutes which was the same as a standard dose of two tablets of 500 mg paracetamol.Phenylephrine should be used with care in patients with cardiovascular disease, diabetes mellitus, closed angle glaucoma and hypertension. Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is recommended. Paracetamol is excreted in breast milk, but not in a clinically significant amount. Available published data do not contraindicate breast feeding.

It comes in a few different variations and has plenty of tablet alternatives if you do not want to have your medicine in a sachet form.Paracetamol and phenylephrine/ pseudoephedrine work in two ways to relieve symptoms. The exact way paracetamol works is still unknown but it is a well established and safe treatment for mild to moderate pain. The decongestants reduce swelling of the sinus passages of the nose. This opens up the airways and relieves pressure build-ups which can cause pain. What alternatives are there for Lemsip? The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T1 /2 of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine. contains Paracetamol 500 mg, Guaifenesin 100 mg Phenylephrine hydrochloride 6.1 mg Indications: For the relief of symptoms of colds and

reactions, precautions, contra-indications, and method of use can be found at: http://www.medicines.org.uk/emc/medicine/23352 for All-in-OneThe safety of this medicine during pregnancy and lactation has not been established but in view of a possible association of foetal abnormalities with first trimester exposure to phenylephrine, the use of the product during pregnancy should be avoided. In addition, because phenylephrine may reduce placental perfusion, the product should not be used in patients with a history of preeclampsia. Paracetamol is excreted in breast milk, but not in a clinically significant amount. Available published data do not contraindicate breastfeeding. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous Nacetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.