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Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Viikinkaari 5D, 00014 Helsinki, Finland. [email protected] Zhang J, Sun B, Shen W, Wang Z, Liu Y, Sun Y, Zhang J, Liu R, Wang Y, Bai T, Ma Z, Luo C, Qiao X, Zhang X, Yang S, Sun Y, Jiang D, Yang K. Zhang J, et al. Vaccines (Basel). 2023 Oct 20;11(10):1620. doi: 10.3390/vaccines11101620. Vaccines (Basel). 2023. PMID: 37897022 Free PMC article. Höning S, Sandoval IV, von Figura K (Aug 1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3". The EMBO Journal. 17 (5): 1304–14. doi: 10.1093/emboj/17.5.1304. PMC 1170479. PMID 9482728. The Blagdon Inpond 5 in 1 6000 Pond filter also features a 9w UVC clarifier to ensure the best possible water clarity levels. The clarifier is integrated into the kills' of the pond filter to effectively reduce and control green water in ponds for crystal clear results. PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysosome-associated membrane glycoprotein 1

LAMP-1-deficient Normal Lysosomal Morphology and Function in LAMP-1-deficient

Lysosomal-associated membrane protein 1 ( LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a ( Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34). Fehrenbacher N, Bastholm L, Kirkegaard-Sørensen T, Rafn B, Bøttzauw T, Nielsen C, Weber E, Shirasawa S, Kallunki T, Jäättelä M. Fehrenbacher N, et al. Cancer Res. 2008 Aug 15;68(16):6623-33. doi: 10.1158/0008-5472.CAN-08-0463. Cancer Res. 2008. PMID: 18701486Zhang H, Li XJ, Martin DB, Aebersold R (Jun 2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nature Biotechnology. 21 (6): 660–6. doi: 10.1038/nbt827. PMID 12754519. S2CID 581283. Furuta K, Yang XL, Chen JS, Hamilton SR, August JT (May 1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues". Archives of Biochemistry and Biophysics. 365 (1): 75–82. doi: 10.1006/abbi.1999.1147. PMID 10222041. Aqualease Ltd t/a Complete Aquatics is authorised and regulated by the Financial Conduct Authority, register number 729918 and act as a credit broker and not a lender. Sawada R, Jardine KA, Fukuda M (Apr 1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes". The Journal of Biological Chemistry. 268 (12): 9014–22. doi: 10.1016/S0021-9258(18)52972-0. PMID 8517882.

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Custom Neon Sign | Neon Sign | Personalized Gifts | Wedding Signs | Name Signs | Led Neon Lights | Neon Signs | Neon Sign bar Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P. Tanaka Y, et al. Nature. 2000 Aug 24;406(6798):902-6. doi: 10.1038/35022595. Nature. 2000. PMID: 10972293 Wooden Small Lamp, Industrial Minimal Style, Rectangle Refurbished Wood Desk Lamp, Table Lamp, Free Personalized Tag, Christmas GiftLee N, Wang WC, Fukuda M (Nov 1990). "Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins". The Journal of Biological Chemistry. 265 (33): 20476–87. doi: 10.1016/S0021-9258(17)30529-X. PMID 2243101. Raposo G, Moore M, Innes D, Leijendekker R, Leigh-Brown A, Benaroch P, Geuze H (Oct 2002). "Human macrophages accumulate HIV-1 particles in MHC II compartments". Traffic. 3 (10): 718–29. doi: 10.1034/j.1600-0854.2002.31004.x. PMID 12230470. S2CID 7055266.

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Laferte S, Dennis JW (Apr 1989). "Purification of two glycoproteins expressing beta 1-6 branched Asn-linked oligosaccharides from metastatic tumour cells". The Biochemical Journal. 259 (2): 569–576. doi: 10.1042/bj2590569. PMC 1138546. PMID 2719668.Obviously I never heard of such a thing until tonight. Google revealed it's one of those tiktok crazes and I looked at the options. Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail [6] exposed to the cytoplasm. [8] The extracytoplasmic region contains a hinge-like structure which can form disulphide bridges homologous to those observed in human immunoglobulin A. [8] Other characteristics of the structure of the LAMP-1 glycoproteins include: LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, [6] and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. [6] [11] The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. [11] The two are therefore thought to share similar functions in vivo. [6] However, this makes the determining the precise function of LAMP1 difficult, because while the LAMP1 deficient phenotype is little different than the wild type due to LAMP2 up regulation, [6] [11] the LAMP1/ LAMP2 double deficient phenotype leads to embryonic lethality. [11] Polylactosamine attachments which protect the glyocoprotein from degradation by lysosomal proteases [10]