Janeway's Immunobiology

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Newly synthesized MHC class I molecules are retained in the endoplasmic reticulum until they bind peptide Complement control proteins regulate all three pathways of complement activation and protect the host from its destructive effects Immunobiology is the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope. Every chapter is reviewed with experts to ensure accuracy, authority, currency, and depth. The Tenth Edition is supported by InQuizitive, Norton’s award-winning, easy-to-use adaptive learning tool that helps students learn immunological terms and apply them conceptually. Table of Contents: Susceptibility to autoimmune disease is controlled by environmental and genetic factors, especially MHC genes

Paul Ehrlich advanced the development of an antiserum as a treatment for diphtheria and developed methods to standardize therapeutic serums.The variable chains of lymphocyte antigen receptors are associated with invariant accessory chains that carry out the signaling function of the receptor Many genes that operate in fruit fly immunity also operate in humans and plants and appear to be universal components of host defense Stages in B-cell development are distinguished by the expression of immunoglobulin chains and particular cell-surface proteins We are continually exposed to microorganisms, many of which cause disease, and yet become ill only rarely.

T cells specific for self antigens can cause direct tissue injury and have a role in sustained autoantibody responses In the early 1890s, Emil von Behring and Shibasaburo Kitasato discovered that the serum of animals immune to diphtheria or tetanus contained a specific ‘antitoxic activity’ that could confer short-lived protection against the effects of diphtheria or tetanus toxins in people.

Contents

Live-attenuated viral vaccines are usually more potent than ‘killed’ vaccines and can be made safer by using recombinant DNA technology Only thymocytes whose receptors can interact with self MHC:self peptide complexes can survive and mature It was soon clear that specific antibodies could be induced against a vast range of substances, called antigens because they could stimulate antibody generation.